He affects the composition of the normal bacterial flora of the colon. The detailed mechanism of action of the drug is unknown. Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacteria. There is no occurrence of drug-resistant strains, was observed as Cross-resistance with other antibacterial drugs. Nifuroxazide effectiveness does not depend on the pH that exists in the intestinal lumen or the sensitivity of microorganisms to antibiotics. The drug is practically not absorbed from the digestive tract, it operates exclusively in the intestinal lumen. Durabolin nifuroxazide difficult to dissolve. Following oral administration is practically not absorbed from the digestive tract and has no systemic effect. Displayed through the intestines.


Indications for use
Acute and chronic diarrhea due to enteric gram-positive bacteria (Staphylococcs spp., Streptococcus spp. , Haemophylus influenzae), as well as some Gram negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp.).

Allergic reactions to 5-nitrofuran, children under 6 years.

Pregnancy and lactation
With caution used during durabolin pregnancy and lactation.

Dosing and Administration
Inside. Adults and children over 6 years: 2 tablets (200 mg) 4 times a day after 6 hours. The course of treatment – 6 days. Before use, you must consult your doctor.

Side effects
nifuroxazide well tolerated, side effects are practically not observed. In rare cases, the presence of individual hypersensitivity to nifuroxazide, there may be abdominal pain, nausea and increased diarrhea (these symptoms do not require special treatment and discontinuation).

Signs of overdose have not been described.
In the case of overdose recommended gastric lavage and symptomatic treatment.

Interactions with other drugs
Because nifuroxazide is not absorbed from the digestive tract, the possibility of interaction with other drugs is unlikely.

During treatment must be administered orally or parenterally depending on the condition of the patient, to make up the loss of fluids.
Drinking alcohol during treatment may cause nifuroxazide disulfiramopodobnyh durabolin reaction.

Effects on ability to management of motor transport and work with mechanisms .
The drug does not affect the ability to drive a car and work with other mechanisms. steroiden kaufen

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